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nlmixr2
7.0.1
Articles
Getting started
Introduction to Running Nlmixr
Using Multiple Endpoints in Nlmixr
Going further
Model Piping
Sweeping models to tidy datasets (broom)
Censoring in nlmixr2 (M3 and others)
Mixture models (latent subpopulations)
Separate phase 1 and phase 3 residual error
Simulations with individually-titrated dosing
Integrated development with xgxr/nlmixr/ggPMX
For contributors
Contributing a long-running example (precompute + cache)
Citations of nlmixr2
Who we are
Example models
Phenobarbatol with correlations
Nonlinear PK/PD -- Nimotuzumab
PBPK -- Mavoglurant
PKPD -- Myelosuppression model
DDEs -- Lifespan and delayed-response models
VAE-NLME -- neonatal growth with covariate selection
Estimation: conditional/quadrature ladder (fo...agq)
Priors in FOCEi: general, nwpri and tnpri
Estimation: SAEM
Estimation: NLM-family optimizers (population-only)
Estimation: external engines via babelmixr2
Estimation: importance-sampling EM (imp/impmap/qrpem)
Nonparametric NLME (npag/npb) vs Pmetrics
Variational inference (emvi/fbvi) vs FOCEI/SAEM/Stan/VAE
Cheat Sheet
Tutorial
Functions
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